Io Rune in Diablo 2 Resurrected

All runes · Rune #16 of 33 · Required level 35

The Io rune can be socketed for the bonuses below or saved for a runeword. Its effect depends on the equipment slot; a rune by itself does not create a runeword.

Io rune socket effects

• Weapon: +10 Vitality
• Armor / Helm: +10 Vitality
• Shield: +10 Vitality

Io rune Cube recipes

How to make a Io rune

3 Hel Runes + 1 Chipped Diamond → 1 Io Rune

How to upgrade Io

3 Io Runes + 1 Flawed Topaz → 1 Lum Rune

Place the listed ingredients in the Horadric Cube and transmute. Upgrading consumes those ingredients; check your planned runewords before spending runes. View all rune upgrade formulas.

Where to farm Io runes

Reference farming areas from the app:

• Nightmare Countess
• Hell Act 1-3

Rune drops depend on difficulty, monster or chest type, and game settings. These are farming suggestions, not guaranteed drops or a fixed drop rate. The Countess's special rune table reaches Ral in Normal, Io in Nightmare and Ist in Hell; her ordinary item drops are a separate table.

Runewords that use Io

15 runewords in this database use Io. Follow each link for the full stats, compatible base types, sockets and patch requirements.

Previous rune: Hel · Full rune list · Next rune: Lum